NMR and EPR
Additional Information
EMSL houses NMR instruments with frequencies up to 900 MHz, as well as an electron paramagnetic resonance (EPR) spectrometer. EMSL staff are active in developing a variety of probes and techniques to complement their collection of state-of-the-art magnets. NMR capabilities at EMSL are widely used in the following topical areas:
- Interfacial and in situ chemistry – EMSL offers users solid-state NMR techniques for low-gamma nuclei detection and a full range of magic-angle spinning methodologies to study catalytic, advanced material, geochemical, and biological systems in their near-native state and in real time.
Interfacial and in situ biology – NMR resources are available for structural biology investigations to determine the structure of large molecular assemblies and to monitor their changes in response to environmental influences. In addition, EMSL offers tools for functional 'omics research, including metabolomics, and a bio-magic angle spinning (BioMAS)/900-MHz NMR system to explore biological membrane proteins in the solid state.- Environmental chemistry – EMSL offers a unique NMR system for radiological studies. Users can perform magic-angle spinning of highly radioactive samples with a novel triple-containment rotor. These tools allow users to apply NMR techniques to critical areas of radiological research, including study of radioactive waste processing and storage.
- Metallocomplexes – EMSL emphasizes studies of transition metal complexes relevant to biological, environmental, and catalysis systems. BioMAS and low-temperature probes are used to determine conformational changes in membrane protein complexes involving metal clusters as followed by solid-state NMR and by pulsed EPR.
Capability Detail
Refer to the table below for a full listing, which leads to complete information about each of EMSL's NMR and EPR instruments. Brief details about the primary NMR and EPR tools available to EMSL users immediately follow.
- Eleven NMR spectrometers, ranging from 300 MHz to 900 MHz with capabilities for high-field liquid-state, solid-state, and micro-imaging techniques
- One pulsed EPR spectrometer, for probing metal centers in biological and materials systems
- NMR with radiological capabilities
- NMR with metabolomics capabilities to study microbial systems and biofluids
- Extreme-temperature probes, including high-temperature probes to study catalysts in their near-native states and low-temperature probes to study metalloprotein chemistry and structure
- Novel BioMAS/900 MHz system for bio-solid studies
- Combined optical and magnetic resonance microscopy instrument
- Virtual NMR tools for remote access to spectrometer systems
All Related Publications Related Publications
- An integrated top-down and bottom-up strategy for broadly characterizing protein isoforms and modifications.
- Nanotechnology-Based Electrochemical Sensors for Biomonitoring Chemical Exposures .
- Advancements Toward the Greener Processing of Engineered Nanomaterials -- Effect of Core Size on the Dispersibility and Transport of Gold Nanocrystals in Near-Critical Solvents.
- Imaging Consecutive Steps of O2 Reaction with Hydroxylated TiO₂(110): Identification of HO₂ and Terminal OH Intermediates.
- EQCM Immunoassay for Phosphorylated Acetylcholinesterase as a Biomarker for Organophosphate Exposures Based on Selective Zirconia Adsorption and Enzyme-Catalytic Precipitation .
Related Research Highlights
- Probing Reaction Pathways Using in situ 1H NMR Spectroscopy (Hydrogen Does the Two Step)
- The Synergy Between Molecular Theory and Solid-State NMR Spectroscopy (Model System for NMR)
