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Genome organization of organism reflects its "hot" lifestyle

An integrated approach improves genome annotation of Thermotoga maritima

Generation of multiple genome-scale data sets integrated with bioinformatics predictions reveals the genome organization of Thermotoga maritima.

Scientists at the University of California, San Diego and Pacific Northwest National Laboratory used an integrated bioinformatics and multi-omics approach to characterize the genome organization of Thermotoga maritima, a bacterium that grows at high temperatures. Performing a significant portion of their work at EMSL, the scientists’ approach revealed organizational features within the genome of T. maritima that lead to and regulate protein expression. The study was published in PLoS Genetics.

The hyperthermophilic nature of T. maritime enhances the potential utility of the organism for biotechnology applications, such as high-temperature, biologically based chemical production.

Read the full story from the PNNL Fundamental & Computational Sciences Directorate.

Reference: Latif H, JA Lerman, VA Portnoy, Y Tarasova, H Nagarajan, AC Schrimpe-Rutledge, RD Smith, JN Adkins, DH Lee, Y Qiu, and K Zengler. 2013. "The Genome Organization of Thermotoga Maritima Reflects Its Lifestyle." PLoS Genetics 9(4):e1003485. DOI: 10.1371/journal.pgen.1003485.

Released: July 16, 2013