Skip to main content

Arun Sivashanmugam

Institution
Wayne State University

Projects

Structural Determination of Apolipoprotein A-I/preb-HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in the high-density lipoprotein (HDL) pathway, which clears the "bad cholesterol" from human…

NMR Structural Studies of a 180 kDa HDL Particle

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal centers on exploring NMR study of a 180 kDa HDL particle. In particular, we will concentrate on the NMR study of discoidal HDL particle, which is the initial stage of HDL…

Structural Studies of Lipid-free Apolipoprotein A-I

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in clearing the "bad cholesterol" from the human blood stream (reverse cholesterol transport…

NMR Studies of Human Apolipoprotein-AI

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
In this proposal, we plan to focus on determining the NMR structure of lipid-free human apoA-I(1-186). ApoA-I is a 243-residue protein (28.1 kDa), which is the main protein component of HDL, a…

Structural Studies of Lipid-free Apolipoprotein A-I

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Cholesterol is a lipid that is necessary for our body. Only the cholesterol that is in excess in the peripheral cells and blood vessels are the bad cholesterol and need to be transport by the HDL…