Proton and Carbon Chemical Shift Assignments of Brodifacoum
EMSL Project ID
32717
Abstract
Abstract
We are making complete proton and carbon chemical shift assignments of both diastereomers of the potent vitamin K epoxide reductase (VKOR) inhibitor brodifacoum ((3-[3-[4-(4-bromophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-2-hydroxychromen-4-one). To resolve chemical shift degeneracies and overlap observed at 500 MHz, we are seeking 3 days of time on a high field (750 or 900 MHz) liquids instrument.
Project Details
Project type
Limited Scope
Start Date
2008-12-10
End Date
2009-02-09
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
1Hand 13C NMR chemical shift assignments and conformational analysis for the two diastereomers of the vitamin K epoxide reductase inhibitor brodifacoum
John R. Cort and Herman Cho
DOI 10.1002/mrc.2475 Magn. Reson. Chem. (2009)