H. Steven Wiley

Lab Fellow, Biologist

2020

Habowski A.N., J.L. Flesher, J.M. Bates, C. Tsai, K.D. Martin, R. Zhao, and A.K. Ganesan, et al. 2020. "Transcriptomic and Proteomic Signatures of Stemness and Differentiation in the Colon Crypt." Communications Biology 3. PNNL-SA-153928. doi:10.1038/s42003-020-01181-z

Habowski, A. N., J. L. Flesher, J. M. Bates, C. F. Tsai, K. Martin, R. Zhao, A. K. Ganesan, R. A. Edwards, T. Shi, H. S. Wiley, Y. Shi, K. J. Hertel, and M. L. Waterman. 2020. “Transcriptomic and Proteomic Signatures of Stemness and Differentiation in the Colon Crypt.” Communications Biology 3 (1). https://doi.org/10.1038/s42003-020-01181-z.

Gerosa L., C. Chidley, F. Froehlich, G. Sanchez, S.K. Lim, J. Muhlich, and J. Chen, et al. 2020. " Receptor-driven ERK pulses reconfigure MAPK signaling and enable persistence of drug-adapted BRAF-mutant melanoma cells." Cell Systems. PNNL-SA-147461. doi: 10.1016/j.cels.2020.10.002 

2019

Zhang P., M.J. Gaffrey, Y. Zhu, W.B. Chrisler, T.L. Fillmore, L. Yi, and C.D. Nicora, et al. 2019. "Carrier-assisted single-tube processing approach for targeted proteomics analysis of low numbers of mammalian cells." Analytical Chemistry 91, no. 2:1441-1451. PNNL-SA-138130. doi:10.1021/acs.analchem.8b04258

2018

Lee J., G.M. Fujimoto, R.E. Wilson, H. Wiley, and S.H. Payne. 2018. "Blazing Signature Filter: a library for fast pairwise similarity comparisons." BMC Bioinformatics 19. PNNL-SA-126956. doi:10.1186/s12859-018-2210-6

Shi T., M.J. Gaffrey, T.L. Fillmore, C.D. Nicora, L. Yi, P. Zhang, and A.K. Shukla, et al. 2018. "Facile carrier-assisted targeted mass spectrometric approach for proteomic analysis of low numbers of mammalian cells." Communications Biology 1, no. 1:Article No. 103. PNNL-SA-130600. doi:10.1038/s42003-018-0107-6

Wells A., and H. Wiley. 2018. "A Systems Perspective of Heterocellular Signaling." Essays in Biochemistry 62, no. 4:607-617. PNNL-SA-135065. doi:10.1042/EBC20180015

Wiley H. 2018. "Receptors: How low can you go?." eLife 7. PNNL-SA-131431. doi:10.7554/eLife.33604

Yi L., T. Shi, M.A. Gritsenko, C. Chan, T.L. Fillmore, B.M. Hess, and A.C. Swensen, et al. 2018. "Targeted Quantification of Phosphorylation Dynamics in the Context of EGFR-MAPK Pathway." Analytical Chemistry 90, no. 8:5256-5263. PNNL-SA-31519.  doi:10.1021/acs.analchem.8b00071

2017

Bethel E.W., M. Greenwald, K. Kleese van Dam, M. Parashar, S. Wild, and H. Wiley. 2017. "Management, Analysis, and Visualization of Experimental and Observational Data - The Convergence of Data and Computing." In IEEE 12th International Conference on eScience (e-Science 2016), October 23-27, 2017, Baltimore, MD, 213-222. Piscataway, New Jersey: IEEE. PNNL-SA-123213. doi:10.1109/eScience.2016.7870902

Lindemann S.R., J.M. Mobberley, J.K. Cole, L. Markillie, R.C. Taylor, E.L. Huang, and W.B. Chrisler, et al. 2017. "Predicting Species-Resolved Macronutrient Acquisition during Succession in a Model Phototrophic Biofilm Using an Integrated 'Omics Approach." Frontiers in Microbiology 8. PNNL-SA-129376. doi:10.3389/fmicb.2017.01020

Wiley H. 2017. "Decoding Signal Processing at the Single Cell Level." Cell Systems 5, no. 6:542-543. PNNL-SA-131446. doi:10.1016/j.cels.2017.12.003

2016

Shi T., M. Niepel, J.E. McDermott, Y. Gao, C.D. Nicora, W.B. Chrisler, and L.M. Markillie, et al. 2016. "Conservation of Protein Abundance Patterns Reveals the Regulatory Architecture of the of the EGFR-MAPK Pathway." Science Signaling 9, no. 436:rs6. PNNL-SA-115056. doi:10.1126/scisignal.aaf0891

2014

Beliaev A.S., M.F. Romine, M. Serres, H.C. Bernstein, B.E. Linggi, L.M. Markillie, and N.G. Isern, et al. 2014. "Inference of Interactions in Cyanobacterial-Heterotrophic Co-Cultures via Transcriptome Sequencing." The ISME Journal 8, no. 11:2243-2255. PNNL-SA-98626. doi:10.1038/ismej.2014.69

Shi T., Y. Gao, M.J. Gaffrey, C.D. Nicora, T.L. Fillmore, W.B. Chrisler, and M.A. Gritsenko, et al. 2014. "Sensitive Targeted Quantification of ERK Phosphorylation Dynamics and Stoichiometry in Human Cells without Affinity Enrichment." Analytical Chemistry 87, no. 2:1103-1110. PNNL-SA-103421. doi:10.1021/ac503797x

Wiley H.S. 2014. "Open questions: The disrupted circuitry of the cancer cell." BMC Biology 12. PNNL-SA-106172. doi:10.1186/s12915-014-0088-y

Zhou Z.N., V.P. Sharma, B.T. Beaty, M. Roh-Johnson, E.A. Peterson, N. Van Rooijen, and P.A. Kenny, et al. 2014. "Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo." Oncogene 33, no. 29:3784-3793. PNNL-SA-105934. doi:10.1038/onc.2013.363

2013

Hess B.M., J. Xue, L.M. Markillie, R.C. Taylor, H.S. Wiley, B.K. Ahring, and B.E. Linggi. 2013. "Coregulation of terpenoid pathway genes and prediction of isoprene production in Bacillus subtilis using transcriptomics." PLoS One 8, no. 6:e66104. PNNL-SA-93488. doi:10.1371/journal.pone.0066104

Taylor R.C., B.M. Webb-Robertson, L.M. Markillie, M.H. Serres, B.E. Linggi, J.T. Aldrich, and E.A. Hill, et al. 2013. "Changes in Translational Efficiency is a Dominant Regulatory Mechanism in the Environmental Response of Bacteria." Integrative Biology 5, no. 11:1393-1406. PNNL-SA-95628. doi:10.1039/C3IB40120K

2012

Shankaran H., Y. Zhang, W.B. Chrisler, J.A. Ewald, H.S. Wiley, and H. Resat. 2012. "Integrated Experimental and Model-based Analysis Reveals the Spatial Aspects of EGFR Activation Dynamics." Molecular Biosystems 8, no. 11:2868-2882. PNNL-SA-80743. doi:10.1039/C2MB25190F

Waters K.M., T. Liu, R.D. Quesenberry, A.R. Willse, S. Bandyopadhyay, L.E. Kathmann, and T.J. Weber, et al. 2012. "Network Analysis of Epidermal Growth Factor Signaling using Integrated Genomic, Proteomic and Phosphorylation Data." PLoS One 7, no. 3:Article No. e34515. PNNL-SA-85737. doi:10.1371/journal.pone.0034515

Wiley H.S. 2012. "Cooking Up Creative Solutions." The Scientist 26, no. 5:26-27. PNNL-SA-88063.

2011

Ahring B.K., N.S. Baliga, J.R. Frederickson, S. Kaplan, H.B. Pakrasi, J.G. Pounds, and I. Shah, et al. 2011. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP). PNNL-20717. Richland, WA: Pacific Northwest National Laboratory. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP)

Brown G.E., A. Chaka, D.K. Shuh, E.E. Roden, C.J. Werth, N.J. Hess, and A.R. Felmy, et al. 2011. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting. PNNL-20601. Richland, WA: Pacific Northwest National Laboratory. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting

Labaj P.P., G.G. Leparc, B.E. Linggi, L.M. Markillie, H.S. Wiley, and D.P. Kreil. 2011. "Characterization and Improvement of RNA-Seq Precision in Quantitative Transcript Expression Profiling." Bioinformatics 27, no. 13:I383-I391. PNNL-SA-77408. doi:10.1093/bioinformatics/btr247

Wiley H.S. 2011. "At the Tipping Point." The Scientist 25, no. 2:28. PNNL-SA-77373.

Wiley H.S. 2011. "Integrating Multiple Types of Data for Signaling Research: Challenges and Opportunities." Science Signaling 4, no. 160:pe9. PNNL-SA-77372. doi:10.1126/scisignal.2001826

2010

Joslin E.J., H. Shankaran, L.K. Opresko, N. Bollinger, D.A. Lauffenburger, and H.S. Wiley. 2010. "Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context." Molecular Systems Biology 6, no. 7:1293-1306. PNNL-SA-66134. doi:10.1039/c003921g

Prince R.N., E.R. Schreiter, P. Zou, H.S. Wiley, A.Y. Ting, R.T. Lee, and D.A. Lauffenburger. 2010. "The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release." Journal of Cell Science 123, no. 13:2308-2318. PNNL-SA-73406. doi:10.1242/jcs.058321

Shankaran H., and H.S. Wiley. 2010. "Oscillatory Dynamics of the Extracellular Signal-regulated Kinase Pathway." Current Opinion in Genetics & Development 20, no. 6:650-655. PNNL-SA-74761. doi:10.1016/j.gde.2010.08.002

Weber T.J., H. Shankaran, H.S. Wiley, L.K. Opresko, W.B. Chrisler, and R.D. Quesenberry. 2010. "Basic Fibroblast Growth Factor Regulates Persistent ERK Osciliations in Premaligant but not Malignant JB6 Cells." Journal of Investigative Dermatology 130, no. 5:144-156. PNNL-SA-59833.

Wiley H.S. 2010. "Down with Reviews." The Scientist 24, no. 4:31. PNNL-SA-72081.

Wiley H.S. 2010. "Keep it Simple." The Scientist 24, no. 5:37. PNNL-SA-72919.

Wiley H.S. 2010. "Mind Your Manners." The Scientist 24, no. 1:23. PNNL-SA-70034.

Wiley H.S. 2010. "One of the Good Guys." The Scientist 24, no. 10:36. PNNL-SA-75424.

Wiley H.S. 2010. "Scientists vs. Engineers." The Scientist 24, no. 7:29. PNNL-SA-74758.

Wiley H.S. 2010. "Think Outside the Bio-Box." The Scientist 24, no. 6:31. PNNL-SA-72920.

Wiley H.S. 2010. "To Join or Not to Join." The Scientist 24, no. 3:33. PNNL-SA-72083.

Wiley H.S. 2010. "Why I Love Vendors." The Scientist 24, no. 2:23. PNNL-SA-72084.

2009

Heibeck T.H., S. Ding, L.K. Opresko, R. Zhao, A.A. Schepmoes, F. Yang, and A.V. Tolmachev, et al. 2009. "An Extensive Survey of Tyrosine Phosphorylation Revealing New Sites in Human Mammary Epithelial Cells." Journal of Proteome Research 8, no. 8:3852-3861. PNNL-SA-63993.

Shankaran H., D.L. Ippolito, W.B. Chrisler, H. Resat, N. Bollinger, L.K. Opresko, and H.S. Wiley. 2009. "Rapid and Sustained Nuclear-Cytoplasmic ERK Oscillations Induced by Epidermal Growth Factor." Molecular Systems Biology 5. PNNL-SA-54421. doi:10.1038/msb.2009.90

Taylor R.C., M. Singhal, D.S. Daly, J.M. Gilmore, W.R. Cannon, K.O. Domico, and A.M. White, et al. 2009. "An analysis pipeline for the inference of protein-protein interaction networks." International Journal of Data Mining and Bioinformatics 3, no. 4) (Sp. Iss. SI:409-430. PNNL-SA-59756. doi:10.1504/IJDMB.2009.029204

Wiley H.S. 2009. "Bring Back Reprint Requests." The Scientist 23, no. 9:29-29. PNNL-SA-68429.

Wiley H.S. 2009. "Collaborations: Challenging, but Key." The Scientist 23, no. 10:29. PNNL-SA-69042.

Wiley H.S. 2009. "Facts First." The Scientist 23, no. 2:29. PNNL-SA-64882.

Wiley H.S. 2009. "Give Young Scientists a Break." The Scientist 23, no. 11:27. PNNL-SA-69043.

Wiley H.S. 2009. "Heroes and Villains." The Scientist 23, no. 5:27-27. PNNL-SA-66133.

Wiley H.S. 2009. "Quitters sometimes win." The Scientist 23, no. 7:27-27. PNNL-SA-67239.

Wiley H.S. 2009. "Speak Your Mind." The Scientist 23, no. 12:25. PNNL-SA-70023.

Wiley H.S. 2009. "Stimulus Application? Not Me." The Scientist 23, no. 6:25. PNNL-SA-66769.

Wiley H.S. 2009. "The Problem of Perception." The Scientist 23, no. 3:31. PNNL-SA-64883.

Wiley H.S. 2009. "Timing is Everything." The Scientist 23, no. 8:25-25. PNNL-SA-67375.

Wiley H.S. 2009. "Why don't we share data?" The Scientist 23, no. 4:33-33. PNNL-SA-65489.

Wiley H.S. 2009. Implementation Plans for a Systems Microbiology and Extremophile Research Facility. PNNL-19073. Richland, WA: Pacific Northwest National Laboratory. Implementation Plans for a Systems Microbiology and Extremophile Research Facility

Zhang Y., L.K. Opresko, H. Shankaran, W.B. Chrisler, H.S. Wiley, and H. Resat. 2009. "HER/ErbB Receptor Interactions and Signaling Patterns in Human Mammary Epithelial Cells." BMC Cell Biology 10. PNNL-SA-64538. doi:10.1186/1471-2121-10-78

2008

Jacobs J.M., K.M. Waters, L.E. Kathmann, D.G. Camp, H.S. Wiley, R.D. Smith, and B.D. Thrall. 2008. "The Mammary Epithelial Cell Secretome and its Regulation by Signal Transduction Pathways." Journal of Proteome Research 7, no. 2:558-569. PNNL-SA-56310. doi:10.1021/pr0704377

Pelletier D.A., G.B. Hurst, L.J. Foote, P.K. Lankford, C.K. McKeown, T.S. Lu, and D.D. Schmoyer, et al. 2008. "A general system for studying protein-protein interactions in gram-negative bacteria." Journal of Proteome Research 7, no. 8:3319-3328. PNNL-SA-58778. doi:10.1021/pr8001832

Rodland K.D., N. Bollinger, D.L. Ippolito, L. Opresko, R.J. Coffey, R.C. Zangar, and H.S. Wiley. 2008. "Multiple Mechanisms are Responsible for Transactivation of the Epidermal Growth Factor Receptor in Mammary Epithelial Cells." Journal of Biological Chemistry 283, no. 46:31477-31487. PNNL-SA-59460. doi:10.1074/jbc.M800456200

Rogers S., M. Girolami, M. Girolami, W. Kolch, K.M. Waters, T. Liu, and B.D. Thrall, et al. 2008. "Investigating the Correspondence Between Transcriptomic and Proteomic Expression Profiles Using Coupled Cluster Models." Bioinformatics 24, no. 24:2894-2900. PNNL-SA-61286. doi:10.1093/bioinformatics/btn553

Wiley H.S. 2008. "Big biology is here to stay." The Scientist 22, no. 8:27. PNNL-SA-62007.

Wiley H.S. 2008. "Hypothesis-free? No such thing." The Scientist 22, no. 5:31. PNNL-SA-60389.

Wiley H.S. 2008. "Hypothesis-free? No such thing." The Scientist 22, no. 5:31. PNNL-SA-61703.

Wiley H.S. 2008. "It's not just about innovation." The Scientist 22, no. 3:33. PNNL-SA-59510.

Wiley H.S. 2008. "My favorite fraud." The Scientist 22, no. 9:29. PNNL-SA-62006.

Wiley H.S. 2008. "No to negative data." The Scientist 22, no. 4:39. PNNL-SA-59968.

Wiley H.S. 2008. "Peer review isn't perfect but it's also not a conspiracy." The Scientist 22, no. 11:31. PNNL-SA-63211.

Wiley H.S. 2008. "Research locally, think globally." The Scientist 22, no. 7:29. PNNL-SA-61209.

Wiley H.S. 2008. "Telling science's stories." The Scientist 22, no. 1:27. PNNL-SA-58288.

Wiley H.S. 2008. "Think Like a Cockroach: How I Survived an Extinction Event in Biological Research." The Scientist 22, no. 2:29. PNNL-SA-58583.

Wiley H.S. 2008. "Waiting for Einstein." The Scientist 22, no. 10:31. PNNL-SA-63212.

Wiley H.S. 2008. "Why national labs?" The Scientist 22, no. 6:31. PNNL-SA-60752.

Wiley H.S., and H. Shankaran. 2008. "Smad Signaling Dynamics: Insights from a Parsimonious Model." Science Signaling 1, no. 36:pe41. PNNL-SA-61962.

2007

Joslin E.J., L. Opresko, A. Wells, H.S. Wiley, and D.A. Lauffenburger. 2007. "EGF-Receptor-Mediated Mammary Epithelial Cell Migration is Driven by Sustained ERK Signaling from Autocrine Stimulation." Journal of Cell Science 120, no. 20:3688-3699. PNNL-SA-54757. doi:10.1242/jcs.010488

Perrine K.A., B.L. Lamarche, D.F. Hopkins, S.E. Budge, L. Opresko, H.S. Wiley, and M.B. Sowa. 2007. "High Speed Method for in Situ Multispectral Image Registration." Microscopy Research and Technique 70, no. 4:382-389. PNNL-SA-52092. doi:10.1002/jemt.20423

Shah A.R., M. Singhal, K.R. Klicker, E.G. Stephan, H.S. Wiley, and K.M. Waters. 2007. "Enabling high-throughput data management systems biology: The Bioinformatics Resource Manager." Bioinformatics 23, no. 7:906-909. PNNL-SA-49327. doi:10.1093/bioinformatics/btm031

Shankaran H., H. Resat, and H.S. Wiley. 2007. "Cell surface receptors for signal transduction and ligand transport - a design principles study." PLoS Computational Biology 3, no. 6:e101. PNNL-SA-51724. doi:10.1371/journal.pcbi.0030101

Shankaran H., H.S. Wiley, and H. Resat. 2007. "Receptor downregulation and desensitization enhance the information processing ability of signaling receptors." BMC Systems Biology 1. PNNL-SA-53292. doi:10.1186/1752-0509-1-48

Sharp J.L., K.K. Anderson, G.B. Hurst, D.S. Daly, D.A. Pelletier, W.R. Cannon, and D.L. Auberry, et al. 2007. "Statistically Inferring Protein-Protein Associations with Affinity Isolation LC-MS/MS Assays." Journal of Proteome Research 6, no. 9:3788-3795. PNNL-SA-57329. doi:10.1021/pr0701106

2006

Shankaran H., H.S. Wiley, and H. Resat. 2006. "Modeling the effects of HER/ErbB1-3 co-expression on receptor dimerization and biological response." Biophysical Journal 90, no. 11:3993-4009. PNNL-SA-47882.

Shankaran H., H.S. Wiley, and H. Resat. 2006. "Modeling the Effects of HER/ErbB1-3 Coexpression on Receptor Dimerization and Biological Response." Biophysical Journal 90, no. 11:3993-4009. PNNL-SA-45412. doi:10.1529/biophysj.105.080580

Wiley H.S. 2006. "Systems Biology." The Scientist Vol. 20 No. 6, no. June 2006:52-57. PNNL-SA-49943.

2005

Dong J., L. Opresko, W.B. Chrisler, G. Orr, R.D. Quesenberry, D.A. Lauffenburger, and H.S. Wiley. 2005. "The Membrane-anchoring Domain of Epidermal Growth Factor Receptor Ligands Dictates Their Ability to Operate in Juxtacrine Mode." Molecular Biology of the Cell 16, no. 6:2984-2998. PNWD-SA-7019.

Hendriks B.S., G. Orr, A.H. Wells, H.S. Wiley, and D.A. Lauffenburger. 2005. "Parsing ERK Activation Reveals Quantitatively Equivalent Contributions From Epidermal Growth Factor Receptor and HER2 In Human Mammary Epithelial Cells." Journal of Biological Chemistry 280, no. 7:6157-6169. PNNL-SA-43533.

Markillie L.M., C.T. Lin, J.N. Adkins, D.L. Auberry, E.A. Hill, B.S. Hooker, and P.A. Moore, et al. 2005. "Simple Protein Complex Purification and Identification Method Suitable for High- throughput Mapping of Protein Interaction Networks." Journal of Proteome Research 4, no. 2:268-274. PNNL-SA-42494. doi:10.1021/pr049847a

Miller J.H., F. Zheng, S. Jin, L. Opresko, H.S. Wiley, and H. Resat. 2005. "A Model of cytokine shedding induced by low doses of gamma radiation." Radiation Research 163, no. 3:337-342. PNNL-SA-40412.

Monine M.I., A.M. Berezhkovskii, E.J. Joslin, H.S. Wiley, D.A. Lauffenburger, and S. Shvartsman. 2005. "Ligand Accumulation in Autocrine Cell Cultures." Biophysical Journal 88, no. 4:2384-2390. PNNL-SA-44686.

Orr G., D. Hu, S. Ozcelik, L. Opresko, H.S. Wiley, and S.D. Colson. 2005. "Cholesterol Dictates the Freedom of EGF Receptors and HER2 in the Plane of the Membrane." Biophysical Journal 89, no. 2:1362-1373. PNNL-SA-44634. doi:10.1529/biophysj.104.056192

2004

Chen W.U., R.L. Woodbury, L.E. Kathmann, L. Opresko, R.C. Zangar, H.S. Wiley, and B.D. Thrall. 2004. "Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha." Journal of Biological Chemistry 279, no. 18:18488-18496. PNNL-SA-40802.

Maly I.V., H.S. Wiley, and D.A. Lauffenburger. 2004. "Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis." Biophysical Journal 86, no. 1:10-22. PNNL-SA-40760.

Resat M.S., J.C. Solinsky, H.S. Wiley, K.A. Perrine, T.A. Seim, and S.E. Budge. 2004. "3-D Multispectral Monitoring of Living-Cell Signaling Using Confocal-Imaging and FPGA Processing." In International Symposium on Biomedical Imaging, 2004 Proceedings, IEEE, 1, 680-683. Piscataway, New Jersey: IEEE. PNNL-SA-41577.

Shvartsman S., H.S. Wiley, and D.A. Lauffenburger. 2004. "Epidermal growth factor receptor signaling in tissue." IEEE Control Systems Magazine 24, no. 4:53-61. PNNL-SA-42510. doi:10.1109/MCS.2004.1316653

Varnum S.M., D.N. Streblow, M.E. Monroe, P. Smith, K.J. Auberry, L. Pasa-Tolic, and D. Wang, et al. 2004. "Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome." Journal of Virology 78, no. 20:10960-10966. PNNL-SA-43398.

Wiley H.S., and G.S. Michaels. 2004. "Should software hold data hostage?" Nature Biotechnology 22, no. 8:1037-1038. PNNL-SA-42214.

2003

Feldhaus M., R.W. Siegel, L. Opresko, J.R. Coleman, J.M. Feldhaus, Y.A. Yeung, and J.R. Cochran, et al. 2003. "Flow-Cytometric Isolation of Human Antibodies from a Nonimmune Saccharomyces cerevisiae Surface Display Library." Nature Biotechnology 21, no. 2:163-170. PNNL-SA-36938.

Hendriks B.S., L. Opresko, H.S. Wiley, and D.A. Lauffenburger. 2003. "Coregulation of Epidermal Growth Factor Receptor/Human Epidermal Growth Factor Receptor 2 (HER2) Levels and Locations: Quantitative Analysis of HER2 Overexpression Effects." Cancer Research 63, no. 5:1130-7. PNNL-SA-41392.

Hendriks B.S., L. Opresko, H.S. Wiley, and D.A. Lauffenburger. 2003. "Quantitative Analysis of HER2-mediated Effects on HER2 and Epidermal Growth Factor Receptor Endocytosis: DISTRIBUTION OF HOMO- AND HETERODIMERS DEPENDS ON RELATIVE HER2 LEVELS." Journal of Biological Chemistry 278, no. 26:23343-23351. PNWD-SA-5918.

Resat H., J.A. Ewald, D.A. Dixon, and H.S. Wiley. 2003. "An Integrated Model of Epidermal Growth Factor Receptor Trafficking and Signal Transduction." Biophysical Journal 85, no. 2:730-743. PNNL-SA-38098.

Wiley H.S. 2003. "Trafficking of ErbB receptors and its influence on signaling." Experimental Cell Research 284, no. 1:78-88. PNNL-SA-41391. doi:10.1016/S0014-4827(03)00002-8

Wiley H.S. 2003. "Trafficking of the ErbB Receptors and its Influence on Signaling." Experimental Cell Research 284, no. 1:78-88. PNWD-SA-5888.

Wiley H.S., S. Shvartsman, and D.A. Lauffenburger. 2003. "Computational modeling of the EGF-receptor system: a paradigm for systems biology." Trends in Cell Biology 13, no. 1:43-50. PNNL-SA-38177.

2002

Buchanan M.V., F. Larimer, H.S. Wiley, S.J. Kennel, T.C. Squier, J.M. Ramsey, and K.D. Rodland, et al. 2002. "Genomes to Life "Center for Molecular and Cellular Systems": A research program for identification and characterization of protein complexes." OMICS. A Journal of Integrative Biology 6, no. 4:287-303. PNWD-SA-6390.

Dewitt A., T. Iida, H. Lam, V. Hill, H.S. Wiley, and D.A. Lauffenburger. 2002. "Affinity Regulates Spatial Range of EGF Receptor Autocrine Ligand Binding." Developmental Biology 250, no. 2:305-316. PNNL-SA-41390.

2001

Burke P., K. Schooler, and H.S. Wiley. 2001. "Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis and Intracellular Trafficking." Molecular Biology of the Cell 12, no. 6:1897-1910. PNWD-SA-5383.

Dewitt A.E., J.Y. Dong, H.S. Wiley, and D.A. Lauffenburger. 2001. "Quantitative Analysis of the EGF Receptor Autocrine System Reveals Cryptic Regulation of Cell Response by Ligand Capture." Journal of Cell Science 114, no. 12:2301-2313. PNWD-SA-5371.

Holtom G.R., B.D. Thrall, B. Chin, H.S. Wiley, and S.D. Colson. 2001. "Achieving molecular selectivity in imaging using multiphoton Raman spectroscopy techniques." Traffic 2, no. 11:781-788. PNNL-SA-35318.

Maheshwari G., H.S. Wiley, and D.A. Lauffenburger. 2001. "Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration." Journal of Cell Biology 155, no. 7:1123-1128. PNNL-SA-36069.

Resat H., H.S. Wiley, and D.A. Dixon. 2001. "Probability-Weighted Dynamic Monte Carlo Method for Reaction Kinetics Simulations." Journal of Physical Chemistry B 105, no. 44:11026-11034. PNNL-SA-34648.

Resat H., H.S. Wiley, and D.A. Dixon. 2001. "Probability-Weighted Dynamic Monte Carlo Method for Reaction Kinetics Simulations." Journal of Physical Chemistry B 105, no. 44:11026-11034. PNNL-SA-38067.

Shvartsman S., M.P. Hagan, A. Yacoub, P. Dent, H.S. Wiley, and D.A. Lauffenburger. 2001. "Autocrine loops with positive feedback enable context-dependent cell signaling." American Journal of Physiology. Cell Physiology 282, no. 3:C545-C559. PNNL-SA-36711.

Wiley H.S., and P.M. Burke. 2001. "Regulation of Receptor Tyrosine Kinase Signaling by Endocytic Trafficking." Traffic 2, no. 1:12-18. PNWD-SA-5372.